Release date: 2016-09-28
The National Day is coming soon, and family gatherings are indispensable, and there is naturally no wine on the table. Especially in China, wine has been given more cultural and political connotations, and even some have lost the taste of the wine itself.
Drinking two cups may increase the mood, but if you drink drunk, it will not only hurt your body and feelings, but sometimes it will be life-threatening.
Then, once you are drunk, is there any reliable hangover trick? In this regard, Chen Xi, the attending physician of the Department of Nephrology, Peking Union Medical College Hospital, believes that to answer this question, we should first talk about why people are drunk.
Why are you drunk?
At the table, after the cup is changed, there will always be some people who are drunk first, while others can be strong to the end. "Actually, the ultimate decision on who to get drunk is not the guts, but the liver's alcohol dehydrogenase and acetaldehyde dehydrogenase." Chen said that the wine enters the mouth, passes through the esophagus, and first "satisfies" the taste of alcohol. It is the stomach and the duodenum.
"The stomach and duodenum probably take up more than 90% of the alcohol absorption. The alcohol absorbed into the blood is rapidly distributed throughout the body with the blood circulation, except that less than 10% of the alcohol is excreted through the urination or respiratory tract, leaving more than 90% Alcohol metabolism goes through the liver," Chen said.
When alcohol enters the liver, it will decompose into acetaldehyde under the action of alcohol dehydrogenase. Acetaldehyde is a substance that is more toxic than ethanol itself. It dilates blood vessels, makes people blush, nervous, and may damage DNA. It is considered to be carcinogenic.
"Fortunately, there is another substance in the liver called aldehyde dehydrogenase 2 (ALDH2). Under its action, acetaldehyde can be converted into acetic acid, part of acetic acid is discharged with urine, and part of acetic acid is further decomposed into energy, carbon dioxide and water. At this point, the toxicity of alcohol has been completely removed." Chen Yu said.
So, what happens if acetaldehyde dehydrogenase 2 goes wrong?
"This will lead to a large accumulation of acetaldehyde in the body, some people will soon blush after drinking, and the activity of ALDH2 is genetically determined." Chen Yu said that more than 30% of Han people will appear to drink blush, known as "Asian red face."
Chen Wei did not agree with the argument that the drinker said that "the amount of alcohol can be slowly developed." He explained that it is only the body's long-term infiltration of alcohol, which is resistant to nerve excitement and blushing. Although people may not be drunk, acetaldehyde accumulates more and more in the body as the amount of alcohol increases. , causing greater harm to the body.
Folk recipes are not reliable
Even if the drunk is risky, it does not stop the alcoholic on the table. To this end, the folks have also begun to circulate "the banquet book" to deal with the displeasure caused by drunkenness.
It has been proposed to add a transparent carbonated beverage to the liquor and try to avoid the trouble of drunkenness with the "eye-blocking method". The effect of this, in Chen Yu's view, not only can't avoid drunkenness, but it is more likely to be drunk. “Carbonated beverages are rich in carbon dioxide gas, which can expand the volume of the stomach and increase the area absorbed by the alcohol; and carbon dioxide can also promote the rate of alcohol entering the jejunum and increase alcohol absorption.â€
Honey water used to be a popular remedy for hangover, because studies have suggested that fructose in honey water can make the body's intake of alcohol disappear in a shorter period of time. However, further studies have found that fructose only increases the efficiency of ethanol dehydrogenase, but has no effect on the acetaldehyde of ethanol.
As far as traditional medicine is concerned, Gegen is the saying of hangover. Chen Hao holds a reservation. "Because studies have shown that Pueraria is an inhibitor of acetaldehyde dehydrogenase 2, drinking Pueraria after drinking a lot of alcohol may increase the risk of acetaldehyde-related tumors."
"In addition, non-steroidal anti-inflammatory drugs such as aspirin can alleviate the headache after drinking, but it is not beneficial to alcohol metabolism, and their intake with alcohol will increase the risk of gastric bleeding and liver damage." Chen Yu said.
Drink less
So, is there a good recipe for hangover?
Chen Yu said that from the metabolic process of alcohol, there may be two ways to be effective in hangover. "One is to delay the absorption of alcohol in the gastrointestinal tract and avoid a sudden increase in the concentration of ethanol in the blood; the other is to increase the amount of alcohol dehydrogenase and acetaldehyde dehydrogenase, or to increase their activity."
For example, eating some food before drinking can slow down the rate of alcohol consumption, and can slightly reduce the absorption of alcohol, and gain some time for the metabolism of alcohol; eat something at any time during drinking, drink water, can promote alcohol in the urine It can also be replenished with water and minerals.
The hangover by increasing the amount of alcohol dehydrogenase and acetaldehyde dehydrogenase and increasing their activity is obviously impossible in Chen Yu's view, because the two are genetically determined. Foreign aid cannot be supplemented at all.
As for the "hangover medicine", why people feel sober and comfortable. Chen Wei said that this is because it contains ingredients such as diuresis, pain relief and excitement, which can alleviate headache and nausea. However, they do not really “hangoverâ€. Instead, they let the liver metabolize alcohol while also “distracting†to deal with it. These foreign drugs will end up burdening the liver.
"Drinking and hurting, hangover is not good. At the wine table, we still try to drink as little as possible." Chen Yu said.
Source: Science Network / Zhang Sizhen
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