Multi-chamber infusion soft bags are currently categorized into two main types in the large-scale infusion industry: liquid-liquid multi-chamber bags and powder-liquid multi-chamber bags. These products are designed to contain different infusion drugs within the same package, separated by virtual welding between chambers. This design ensures that the drugs remain isolated during production, storage, and transportation. In clinical settings, the virtual weld is opened using external force, and after mixing, the product is used immediately, as it is not suitable for long-term storage. Therefore, these multi-chamber soft bags are primarily used for unstable formulations that require on-demand preparation.
This paper focuses on two critical quality factors: the performance of the virtual weld and the barrier properties of multi-chamber infusion soft bags. The strength of the virtual weld is essential for both the safety of the product during storage and transportation and the ease of use in clinical practice. If the weld is too weak, it may break during handling; if it's too strong, it could be difficult to open. To ensure optimal performance, manufacturers carefully control the temperature, time, and pressure during the sealing process.
Labthink’s HST-H3 heat seal tester and XLW (PC) intelligent electronic tensile tester are widely used for testing the heat-sealing strength of these products. During testing, samples are cut directly from the weld joint, and the test is automatically performed by selecting the "heat seal strength" option on the XLW (PC). Additionally, manufacturers often conduct experiments to determine the ideal parameters for temperature, time, and pressure. This requires a combination of the HST-H3 heat sealer and an intelligent tensile testing machine to analyze and optimize the welding process.
Barrier performance is another crucial factor affecting the quality of multi-chamber bags. Both liquid-liquid and powder-liquid types require a protective barrier to prevent oxygen and water vapor from penetrating the packaging. This is especially important because the contact packaging material has relatively low barrier properties. To enhance protection, nitrogen displacement packaging machines are used during production to replace the air inside the bag. As a result, barrier tests typically include measurements of oxygen permeability, nitrogen permeability, and water vapor transmission rate. Labthink’s VAC-V series of differential pressure gas permeameters are specifically designed for such tests.
The application of multi-chamber bags represents a significant advancement in the functionality of infusion soft bags. As a strict requirement in pharmaceutical packaging, these products must meet rigorous testing standards, including tensile strength, elongation, heat-seal strength, film puncture resistance, rubber stopper puncture force, and overall sealing performance. Labthink is a leading provider of inspection instruments and services, offering high-quality solutions for the global pharmaceutical industry. We look forward to expanding our collaboration with pharmaceutical companies and research institutions. For more information, please contact Guo Sijia at gz@labthink.com.
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