Multi-chamber infusion soft bags are currently categorized into two main types in the large-scale infusion industry: liquid-liquid multi-chamber bags and powder-liquid multi-chamber bags. These products are designed to store different infusion drugs within the same package, separated by virtual welding between chambers. During production, storage, and transportation, these chambers remain sealed, and only when clinical use begins is the virtual welding opened by external force. After mixing, the contents are used immediately, as the product is not suitable for long-term storage. This paper focuses on two key quality factors: the performance of the virtual weld and the barrier properties of multi-chamber infusion soft bags.
1. **Analysis and Testing of Weld Strength**
The strength of the virtual weld is crucial for ensuring both the safety of the product during storage and transportation, as well as ease of use in clinical settings. The weld must be strong enough to prevent accidental separation but not so strong that it becomes difficult to open. The effectiveness of the virtual welding mainly depends on three parameters: temperature, time, and pressure during the sealing process. To maintain an optimal balance, manufacturers often conduct extensive testing using specialized equipment. Labthink’s HST-H3 heat seal tester and XLW (PC) intelligent electronic tensile tester are widely used to evaluate the heat-seal strength of multi-chamber bags. During testing, samples are cut directly from the welded area, and the test is initiated by selecting the “heat seal strength†option on the XLW (PC). Additionally, for optimizing the welding process, manufacturers analyze the temperature, time, and pressure parameters using the HST-H3 heat sealing tester in combination with a tensile testing machine.
2. **Analysis and Testing of Barrier Performance**
Barrier performance plays a critical role in maintaining the stability and quality of multi-chamber infusion bags. Whether it's a liquid-liquid or powder-liquid multi-chamber bag, the packaging must effectively block the penetration of oxygen and moisture to protect the contents. To achieve this, a protective inner barrier is often used. In addition, during the production process, nitrogen displacement is commonly employed to replace air inside the bag. Therefore, barrier performance tests typically include measurements of oxygen permeability, nitrogen permeability, and water vapor transmission rate. Labthink’s VAC-V series of differential pressure gas permeameters are capable of performing these essential tests accurately.
The application of multi-chamber bags represents a significant advancement in the functionality of infusion soft bags. As a critical requirement in pharmaceutical packaging, these products must meet strict standards for tensile strength, elongation, heat-seal strength, film puncture resistance, rubber stopper puncture force, and other quality indicators. Labthink is a leading provider of inspection instruments and services, offering comprehensive quality control solutions to the global pharmaceutical industry. With years of experience, we aim to build stronger relationships with companies and institutions in the pharmaceutical sector. For more information, please contact Guo Sijia at gz@labthink.com.
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