Demystifying the molecular mechanism of inflammation leading to cancer

Release date: 2012-11-29

Recently, researchers from the Ohio State University Center for Comprehensive Research on Cancer found that a hormone-like substance produced by the body to promote inflammation in the body is likely to cause malignant leukemia when it is at a high level. Relevant research results are published in the international market. Magazine Cancer Cell.
The study revealed that high levels of interleukin 15 can contribute to the development of granulocyte lymphoblastic leukemia, and researchers have developed a new type of therapy that is currently found in animal models with no side effects. Researcher Michael A. Caligiuri said that we know that inflammation can cause cancer, but we don't know its specific molecular mechanism. Our research reveals its molecular mechanisms and potential new therapies.
Under normal circumstances, the body can release interleukin 15 to stimulate the growth and proliferation of natural killer cells, natural killer cells can destroy cancer cells and virus-infected cells. The researchers revealed that when interleukin 15 (IL-15) is at a high level, it can cause the body to produce large granular lymphocytes (LGLs), which can lead to cancer.
This malignant transformation begins when IL-15 is adsorbed to receptors on the surface of large-granular lymphocytes, after which the protein Myc, which causes cancer in the cell, begins to produce and the level rises sharply. High levels of Myc can lead to chromosomal instability and additional genetic mutations, and they can activate processes such as DNA methylation, which will cause the body to shut down some genes, including important tumor suppressor genes.
In this study, the researchers used LGL leukemia patients and cells isolated from mouse models to study the following conclusions: 1. Exposing human normal large-granular lymphocytes to IL-15 triggers cell proliferation and chromosomes. Unstable and hypermethylation of DNA; 2, excess IL-15 can activate Myc oncogene, which triggers genetic instability, DNA hypermethylation and metastasis of malignant tumors; 3, reveals that Myc upregulation promotes genetic instability Sexual and molecular mechanisms of DNA hypermethylation.
At the same time, the researchers engineered the proteosome inhibitor bortezomib to produce its liposome form, which shuts down the path of cancer, potentially inhibiting the malignant metastasis of cancer, using liposomal bortezomib. Treatment of the mouse model showed that it could achieve a survival rate of 100% within 130 days, while the control model had a mortality rate of 100% within 60 to 80 days. Now researchers are planning to conduct in-depth research and develop new drugs for clinical treatment.

Source: Bio Valley

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