Analysis of ultrasonic extraction principle
Ultrasonic extraction technology is a relatively mature method used in the extraction of active ingredients of Chinese herbal medicines in recent years. Ultrasonic wave is an elastic mechanical vibration wave that can destroy the cells of Chinese herbal medicines, so that the solvent penetrates into the cells of Chinese herbal medicines, thereby accelerating the dissolution of the active ingredients of Chinese herbal medicines, so as to increase the leaching rate. Ultrasonic extraction is mainly based on its three major effects: cavitation effect, mechanical effect and thermal effect. Jining Hengshuo Ultrasonic Machinery has made great achievements in recent years, and hopes to cooperate with the vast number of pharmaceutical factory customers to study and improve the ultrasonic extraction technology, and jointly contribute to the Chinese ultrasonic medicine extraction business!
1 cavitation effect
When the ultrasonic wave propagates in the liquid, the liquid medium is continuously compressed and stretched, and the liquid is resistant to pressure and is not resistant to pulling. If the liquid cannot withstand such tensile force, it will break and form a temporary vacuum similar to the vacuum (especially in the containing In the compression stage, these voids collapse. During the collapse, the internal zui high instantaneous pressure can reach tens of thousands of atmospheres, and at the same time, local high temperature and discharge phenomenon will occur, which is cavitation.
In the extraction process of traditional Chinese medicine, the cavitation effect is caused by the ultrasonic action of the medicinal material in the medicine, so that the cavitation bubble generated by the ultrasonic wave instantaneously collapses, and the blasting of the cavitation bubble forms a huge jet rushing to the plant. The solid surface allows the solvent to quickly penetrate into the internal cells of the material, thereby breaking the cell wall by the impact of the cavitation bubble, so that the intracellular chemical components directly contact the medicinal material under the action of ultrasound, accelerating the active ingredients in the solvent and the medicinal material. Interpenetrating and rapidly dissolving into the solvent, causing a difference in concentration outside the cell to promote the diffusion of the chemical component from the high concentration solution to the low concentration solution, greatly accelerating the extraction process, and the chemical components in the cell are rapidly transferred to the solvent in the cell. The biological activity of the broken instant remains unchanged, and the breaking speed and the rate of presentation can be improved.
2 mechanical effect
The mechanical effect is that during the propagation of ultrasonic waves in a liquid, the propagating machinery can cause the liquid particles to vibrate in the space of their propagation, thereby enhancing the diffusion and mass transfer of the liquid.
The mechanical effect is accompanied by the generation of cavitation effects, mainly caused by the radiation pressure and the ultrasonic pressure. Radiation pressure can cause two effects, one is the simple turbulence effect, and the other is the friction between the solvent and the medicinal material. This turm can denature proteins and deform tissue. The ultrasonic pressure will give the solvent and the medicinal tissue different accelerations, that is, the velocity of the solvent molecules is much faster than the velocity of the medicinal material, thereby generating friction between them, which is enough to break the bond between the two carbon atoms and dissolve the biomolecules. Gather. The active ingredient on the cell wall is dissolved in a solvent.
3 thermal effects
When ultrasonic waves propagate in a liquid, their mechanical energy is absorbed by the medium and converted into heat energy, which causes the temperature of the medium itself to rise, which in turn causes various effects on the liquid, which is called the thermal effect of ultrasound.
The thermal effect is accompanied by the generation of cavitation effects. The amount of heat generated is mainly determined by the absorption of ultrasonic energy by the medium, and most or all of the absorbed energy will be converted into heat energy, resulting in an increase in the temperature of the tissue. This temperature rise caused by the absorption of acoustic energy is stable. Therefore, the ultrasonic wave can instantaneously increase the temperature inside the medicinal tissue and accelerate the dissolution of the active ingredient.
In addition, ultrasound can also produce many secondary effects such as emulsification, diffusion, crushing, chemical effects, and the like. These effects also promote the dissolution of the active ingredients in the plant, promote the entry of the active ingredient into the medium, and mix well with the medium.
In short, the process of ultrasonic extraction and separation of the chemical constituents of Chinese herbal medicines is the cavitation effect of ultrasonic in the liquid-solid extraction and separation process and the accompanying various secondary effects, which promotes the dissolution of components into liquids. Accelerate the extraction and separation process to increase the extraction rate of ingredients in the herbs.
Disposable Skin Preparation Kits,Sterilized Skin Preparation Kits,Hospital Disposable Skin Preparation Kits,Disposable Skin Preparation Kits For Surgery
Henan Xianghe Medical Materials Co., Ltd. , https://www.xiangheweicai.com