According to "Daily Science", scientists have studied a toxin extracted from bee venom, and new treatments designed with this toxin can alleviate the symptoms of some diseases, such as muscle atrophy, depression and Alzheimer's disease.
Bee neurotoxin, a natural peptide toxin, blocks a type of ion channel that allows potassium ions to flow out of the nerve at high speed and selectively. If these channels in the brain are blocked, the nerves are stimulated intermittently and the learning ability is improved, and it can be used to treat dementia and depression. In addition, injection of bee neurotoxin can also improve the symptoms of patients with muscular dystrophy.
Little is known about the mechanism of action of bee neurotoxins. In a paper published in The Journal of Biological Chemistry, two teams from the University of Bristol and the University of Liège in Belgium described the results of these KCa2 potassium channels, also known as the SK channel.
Using computer models and genetic methods, researchers can pinpoint the ion channels bound by bee neurotoxins. In order to block the ion channel, most of the molecular ions block the outlet externally. Surprisingly, researchers have discovered that bee neurotoxins block ion pores by linking long-distance pore channels by changing the shape of the pores through a “allosteric†mechanism.
This discovery may speed up the design of a new SK blocker that mimics the action of bee neurotoxins and improves nerve and muscle conditions through the SK target channel.
Professor Neil Mulren of the Department of Physiology and Pharmacology at the University of Bristol said: "Drug design depends on knowing the target. Our findings provide a new way to design a therapeutic agent under certain conditions. Can help with treatment."
Bee neurotoxin, a natural peptide toxin, blocks a type of ion channel that allows potassium ions to flow out of the nerve at high speed and selectively. If these channels in the brain are blocked, the nerves are stimulated intermittently and the learning ability is improved, and it can be used to treat dementia and depression. In addition, injection of bee neurotoxin can also improve the symptoms of patients with muscular dystrophy.
Little is known about the mechanism of action of bee neurotoxins. In a paper published in The Journal of Biological Chemistry, two teams from the University of Bristol and the University of Liège in Belgium described the results of these KCa2 potassium channels, also known as the SK channel.
Using computer models and genetic methods, researchers can pinpoint the ion channels bound by bee neurotoxins. In order to block the ion channel, most of the molecular ions block the outlet externally. Surprisingly, researchers have discovered that bee neurotoxins block ion pores by linking long-distance pore channels by changing the shape of the pores through a “allosteric†mechanism.
This discovery may speed up the design of a new SK blocker that mimics the action of bee neurotoxins and improves nerve and muscle conditions through the SK target channel.
Professor Neil Mulren of the Department of Physiology and Pharmacology at the University of Bristol said: "Drug design depends on knowing the target. Our findings provide a new way to design a therapeutic agent under certain conditions. Can help with treatment."
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